Table 1.

Primary information for sixteen Genotyped SNPs

Genotyped SNPs	Chra	Regulome DB Scoreb	Location	TFBSc	Functional Consequence	MAFd for Chinese in database	MAF in our controls (n = 826)	P-value for HWEe test in our controls	Genotyping value (%)
CASP8: rs1035142 G>T	2	No data	3’-Flanking	-	downstream variant 500 B	0.279	0.283	0.612	97.3
CASP7: rs3127075 G>C	10	No data	Intron2	-	intron variant	0.140	0.180	0.946	98.9
CASP7: rs7907519 C>A	10	4	5’-UTR_intron1	-	intron variant	0.289	0.278	0.977	99.5
FAS: rs2234767 G>A	10	4	5’-Flanking	Y	upstream variant 2 KB	0.358	0.335	0.977	98.7
FASL/FASLG: rs763110 C>T	1	2a	5’-Flanking	Y	upstream variant 2 KB	0.298	0.255	0.245	99.3
TP53BP1: rs560191 G>C	15	1f	nonsynon_exon9	-	missense	0.444	0.431	0.003	97.7
BCL2: rs17757541 C>G	18	6	Intron3	-	intron variant	0.134	0.149	0.583	99.3
BCL2: rs12454712 T>C	18	2b	Intron3	-	intron variant	0.477	0.460	0.378	99.4
ERBB2: rs1136201 A>G	17	4	nonsynon_exon17	-	missense	0.221	0.121	0.678	97.4
VEGFR2/KDR: rs11941492 C>T	4	No data	Intron8	-	intron variant	0.314	0.327	0.615	99.4
C1orf10/CRNN: rs3753443 C>T	1	No data	5’-Flanking	Y	upstream variant 2 KB	0.456	0.435	0.853	98.0
C1orf10/CRNN: rs3753444 C>G	1	6	5’-Flanking	Y	upstream variant 2 KB	0.456	0.436	0.944	99.5
C1orf10/CRNN: rs3753446 C>A	1	No data	5’-Flanking	Y	upstream variant 2 KB	0.467	0.458	0.700	99.2
C1orf10/CRNN: rs3829868 C>T	1	No data	nonsynon_exon3	-	missense	0.456	0.437	0.886	99.1
C1orf10/CRNN: rs4285700 C>A	1	6	5’-Flanking	Y	upstream variant 2 KB	0.453	0.436	0.960	99.5
C1orf10/CRNN: rs10888486 C>T	1	No data	3’-UTR_exon3	-	utr variant 3 prime	0.453	0.437	0.951	98.8

^aChr, chromosome;

^bhttp://www.regulomedb.org/;

^cTFBS, transcription factor binding site (http://snpinfo.niehs.nih.gov/snpinfo/snpfunc.htm);

^dMAF, minor allele frequency, FAS rs2234767 G>A and C1orf10/CRNN rs3753446 C>A MAF is in CHB+JPT population;

^eHWE, Hardy-Weinberg equilibrium.