Table 2.
Relationship of the genotypes and alleles distribution TNF-α and IL10 polymorphisms with AS susceptibility
| Polymorphism | Genotypes/alleles | Case/n (%) | Control/n (%) | OR (95% CI) | P |
|---|---|---|---|---|---|
| TNF-α | |||||
| rs3093662 | AA | 18 (21.43) | 25 (27.17) | 1.00 | |
| AG | 41 (48.81) | 47 (51.09) | 1.21 (0.58-2.53) | 0.61 | |
| GG | 25 (29.76) | 20 (21.74) | 1.74 (0.75-1.04) | 0.20 | |
| A | 77 (45.83) | 97 (52.72) | 1.00 | ||
| G | 91 (54.17) | 87 (47.28) | 1.32 (0.87-2.00) | 0.20 | |
| IL10 | |||||
| rs1878672 | GG | 60 (71.43) | 78 (84.78) | 1.00 | |
| CG+CC | 24 (28.57) | 14 (15.22) | 2.23 (1.06-4.67) | 0.03 | |
| G | 139 (82.74) | 167 (90.76) | 1.00 | ||
| C | 29 (17.26) | 17 (9.24) | 2.05 (1.08-3.89) | 0.03 | |
| rs3021094 | CC | 34 (40.48) | 33 (35.87) | 1.00 | |
| CA | 35 (41.67) | 41 (44.56) | 0.83 (0.43-1.60) | 0.58 | |
| AA | 15 (17.86) | 18 (19.57) | 0.81 (0.35-1.87) | 0.62 | |
| C | 103 (61.31) | 107 (58.15) | 1.00 | ||
| A | 65 (38.69) | 77 (41.85) | 0.88 (0.57-1.34) | 0.55 | |
| rs3024490 | TT | 33 (39.29) | 50 (54.35) | 1.00 | |
| TG | 39 (46.43) | 36 (39.13) | 1.64 (0.87-3.09) | 0.12 | |
| GG | 12 (14.28) | 6 (6.52) | 3.03 (1.04-8.87) | 0.04 | |
| T | 105 (62.50) | 136 (73.91) | 1.00 | ||
| G | 63 (37.50) | 48 (26.09) | 1.70 (1.08-2.68) | 0.02 |