Table 2.
Genotype frequencies of IL-16 rs4778889, rs11556218 and rs8034928 among the cases with RCC and controls and their association with risk of RCC
| Genotypes | Patients | % | Controls | % | χ2 test | P value | HWE | OR (95% CI)1 | P value |
|---|---|---|---|---|---|---|---|---|---|
| rs4778889 | |||||||||
| Codminant | |||||||||
| TT | 82 | 45.30 | 160 | 57.55 | 1.0 (Ref.) | - | |||
| TC | 77 | 42.54 | 106 | 38.13 | 1.42 (0.93-2.15) | 0.08 | |||
| CC | 22 | 12.15 | 12 | 4.32 | 12.75 | 0.002 | 0.28 | 3.58 (1.59-8.31) | <0.001 |
| Dominant | |||||||||
| TT | 82 | 45.30 | 160 | 57.50 | 1.0 (Ref.) | - | |||
| TC+CC | 99 | 54.70 | 118 | 42.45 | 6.6 | 0.01 | 1.64 (1.10-2.43) | 0.01 | |
| Recessive | |||||||||
| TT+TC | 159 | 87.85 | 266 | 95.68 | 1.0 (Ref.) | - | |||
| CC | 22 | 12.15 | 12 | 4.32 | 9.82 | 0.002 | 3.07 (1.40-6.98) | 0.002 | |
| rs11556218 | |||||||||
| Codminant | |||||||||
| TT | 94 | 51.93 | 155 | 55.76 | 1.0 (Ref.) | - | |||
| TG | 75 | 41.44 | 108 | 38.85 | 1.15 (0.76-1.72) | 0.5 | |||
| GG | 12 | 6.63 | 15 | 5.40 | 0.76 | 0.68 | 0.49 | 1.32 (0.54-3.16) | 0.5 |
| Dominant | |||||||||
| TT | 94 | 51.60 | 155 | 55.70 | 1.0 (Ref.) | - | |||
| TG+GG | 87 | 48.07 | 123 | 44.24 | 0.65 | 0.42 | 1.17 (0.79-1.73) | 0.42 | |
| Recessive | |||||||||
| TT+TG | 169 | 93.37 | 263 | 94.60 | 1.0 (Ref.) | - | |||
| GG | 12 | 6.63 | 15 | 5.40 | 0.3 | 0.58 | 1.24 (0.52-2.93) | 0.58 | |
| rs8034928 | |||||||||
| Codminant | |||||||||
| TT | 95 | 52.49 | 154 | 55.40 | 1.0 (Ref.) | - | |||
| TC | 73 | 40.33 | 109 | 39.21 | 1.09 (0.72-1.64) | 0.68 | |||
| CC | 13 | 7.18 | 15 | 5.40 | 0.78 | 0.68 | 0.45 | 1.40 (0.59-3.32) | 0.39 |
| Dominant | |||||||||
| TT | 95 | 52.49 | 154 | 55.40 | 1.0 (Ref.) | - | |||
| TC+CC | 86 | 47.51 | 124 | 44.60 | 0.37 | 0.54 | 1.12 (0.76-1.67) | 0.54 | |
| Recessive | |||||||||
| TT+TC | 168 | 92.82 | 263 | 94.60 | 1.0 (Ref.) | - | |||
| CC | 13 | 7.18 | 15 | 5.40 | 0.61 | 0.43 | 1.36 (0.58-3.14) | 0.43 |
1
Adjusted for sex, age, hypertension and diabetes.