Table 1.
Previous reports of cases of pulmonary hypertension with amyloidosis
| Case | Author (year) | Age (sex) | Pattern of pulmonary amyloid deposition (method of detection) | PAP (mmHg) | Amyloidosis type | MM |
|---|---|---|---|---|---|---|
| 1 | Shiue ST, et al (3) (1988) | 65 (F) | Diffuse vascular deposition with little in alveolar capillaries (open lung biopsy) | 39 | AL | (+) |
| 2 | Johnson WJ, et al (4) (1991) | 48 (F) | Small blood vessels including alveolar capillaries (autopsy) | 97 | AA-FMF | (-) |
| 3 | Lutz AE, et al (5) (1995) | 61 (F) | Small peripheral vessels (autopsy) | 75* | β2M | (-) |
| 4 | Chapman AD, et al (6) (1999) | 91 (F) | Alveolar septum (autopsy) | ND | AL | (-) |
| 5 | Dingli D, et al (7) (2001) | 61 (F) | ND | 58 | AL-IgGκ | (+) |
| 6 | Dingli D, et al (7) (2001) | 64 (F) | ND | 36* | AL-IgGλ | (+) |
| 7 | Dingli D, et al (7) (2001) | 82 (M) | ND | 76* | AL-IgGλ | (-) |
| 8 | Dingli D, et al (7) (2001) | 54 (F) | Wide spread vascular deposition (autopsy) | 48 | AL-IgGκ | (-) |
| 9 | Dingli D, et al (7) (2001) | 48 (F) | Wide spread vascular deposition (autopsy) | 62 | AA-FMF | (-) |
| 10 | Erdem H, et al (8) (2006) | 60 (F) | Alveolar septum (lung biopsy) | 40* | AA-FMF | (-) |
| 11 | Eder L, et al (9) (2007) | 73 (F) | ND | 90* | AL | (+) |
| 12 | Lehtonen J, et al (10) (2007) | 48 (M) | ND | 67 | AL-IgGκ | (+) |
| 13 | Arslan S, et al (11) (2015) | 26 (M) | Vasculature of bronchus (transbronchial biopsy) | 65* | AA | (-) |
| 14 | Present case (2015) | 85 (F) | Pulmonary vascular deposition with little in alveolar capillaries (autopsy) | 60* | AL-IgGκ | (+) |
PAP: pulmonary arterial pressure, ND: not described, FMF: familial Mediterranean fever, β2M: beta-2 microglobulin, MM: multiple myeloma.
*
Estimated by echocardiography.