Table 2.

Association between antidepressant use and myocardial infarction

	Percentagea	Events	Model 1b OR (95 % CI)	Model 2c OR (95 % CI)	Model 3d OR (95 % CI)
Analysis 1Ae
Never use	84.9	553	1 (reference)	1 (reference)	1 (reference)
Current antidepressant use	3.7	17	0.82 (0.59–1.14)	0.76 (0.54–1.07)	0.76 (0.54–1.07)
Past antidepressant use	11.4	80	1.14 (0.91–1.42)	1.12 (0.90–1.40)	1.12 (0.89–1.40)
Analysis 1Bf
Never use	85.0	632	1 (reference)	1 (reference)	1 (reference)
Current antidepressant use	3.8	19	0.77 (0.56–1.06)	0.71 (0.51–0.98)	0.71 (0.51–0.98)
Past antidepressant use	11.2	93	1.18 (0.95–1.46)	1.17 (0.95–1.45)	1.17 (0.94–1.44)
Analysis 2g
Past use	11.2	93	1 (reference)	1 (reference)	1 (reference)
Current antidepressant use	3.8	19	0.72 (0.42–1.23)	0.57 (0.32–0.99)	0.56 (0.32–0.99)

Abbreviations: 95 % CI 95 % confidence interval, OR odds ratio

^aAs we studied the associations with time-varying exposure analysis, controls contributed more than once in the computations before they were censored or became a case. For this reason, exposure is reported as a percentage

^bMatched on age and sex, further unadjusted

^cMatched on age and sex, and adjusted for: history of deep venous thrombosis, history of heart failure, systolic and diastolic blood pressure, highest obtained level of education, total cholesterol, high-density lipoprotein cholesterol, smoking, blood-pressure-lowering agents, antithrombotic agents, antipsychotic agents, anxiolytics, hypnotics, depression and anxiety

^dModel 2 and additionally adjusted for the potential intermediate factors: body mass index, HDL cholesterol, total cholesterol, statins and diabetes mellitus

^eAnalyses with never use of antidepressants as reference, using unimputed data

^fAnalyses with never use of antidepressants as reference, using imputed data

^gAnalyses with past use of antidepressants as reference, using imputed data