Table 5.
Selected grade 3 or 4 adverse events from single-agent studies (pooled patient population) vs B2207 and PANORAMA-1 combination trials
| Preferred term Adverse events | 20 mg PAN (tiw qw) (N = 309) n (%) | B2207 All Patients (10–30 mg PAN) + 1.0 or 1.3 mg/m2 BTZ dose (N = 62) n (%) |
PANORAMA-1 20 mg PAN + 1.3 mg/m2 BTZ+ 20 mg Dex (N = 381) n (%) |
|---|---|---|---|
| Anemia | 29 (9) | 11 (18) | 63 (17) |
| Neutropenia | 42 (14) | 17 (27) | 92 (24) |
| Thrombocytopenia | 66 (21) | 50 (81) | 217 (57) |
| Diarrhea | 10 (3) | 10 (16) | 97 (26) |
| Nausea | 6 (2) | 0 | 21 (6) |
| Vomiting | 4 (1) | 3 (5) | 28 (7) |
| Fatigue | 13 (4) | 7 (11) | 65 (17) |