Fig. 3.
WNT-5A-activated signaling cascades in cell migration. Diagrammatic representation of few key signaling cascades engaged by WNT-5A to regulate actin cytoskeletal remodeling and cell migration. ARF6 ADP-ribosylation factor 6, GEF100 ARF-guanine nucleotide exchange protein 100, FlnA filamin A, aPKC atypical protein kinase C, JNK c-Jun N-terminal protein kinase, CapZIP CapZ-interacting protein, DVL disheveled, Daam1 DVL-associated activator of morphogenesis 1, Daple DVL-associating protein with a high frequency of leucine residues, ROCK rho-associated kinase, LRP6 low-density lipoprotein receptor-related protein 6, G G proteins, [Ca 2+]i intracellular calcium release