Figure 2. Antioxidants alleviated hypoxia‐mediated inhibition of BK_Ca channel current density in uterine arteries .

Uterine arteries of pregnant sheep were treated under control (21.0% O₂) and hypoxia (10.5% O₂) for 48 h in the absence or presence of 1 mm N‐acetylcysteine (NAC) or 20 μM EUK 134. BK_Ca currents were normalized to cell capacitance and expressed as picoamps per picofarad (pA pF^–1; y axis), as a function of stepwise 10 mV depolarizing pulses (x axis). Data are means ± SEM of 5–7 cells from five animals of each group. Data were analysed with repeated measures ANOVA. *P < 0.05, hypoxia vs. control in A; +NAC vs. –NAC in B; +EUK 134 vs. –EUK 134 in C.