Table 1.
Direct Fyn substrates in the brain
| Substrate | Site(s) | Outcome of phosphorylation | Refs |
|---|---|---|---|
| PTPRT (Protein Tyrosine Phosphatase Receptor T) | Y912 | Decreases phosphatase activity Promotes homophilic interactions Inhibits synapse formation |
(89) |
| TrkA receptor | ND | Promotes transactivation of TrkA by G-Coupled Protein Receptors (GPCRs) | (13) |
| Nav1.2 | ND | Decreases sodium currents | (90) |
| γ2 subunit GABAA receptor |
Y365, Y367 | Prevents clathrin-mediated endocytosis Enhances synaptic inhibition |
(48) (47) |
| NR2A subunit NMDA receptor |
ND | ND | (91) |
| NR2B subunit NMDA receptor |
Y932, Y1039, Y1070,Y1109, Y1252,Y1336, Y1472 | Y1472: prevents clathrin-mediated endocytosis Y1336: promotes calpain cleavage of NR2B; increased interaction with PI3-K |
(91) (53) (58) (56) (57) |
| TCGAP | Y406 | Negatively regulates activity | (92) |
| p250GAP | ND | Increases association with Fyn | (93) |
| p190RhoGAP | ND | ND | (94) |
| Cdk5 | Y15 | Increases kinase activity Promotes sema3a induced growth cone collapse |
(95) |
| Tau | Y18 | Prevents inhibition of anterograde fast axonal transport | (96) (97) |
| MAP-2c | Y67 | Increased interaction with Grb2 | (98) (99) |
| Psd93 | Y348 | ND | (78) |
| Psd95 | Y523 | Increases NMDA receptor currents | (73) |
| rSLM-1 | ND | Prevents splice site selection | (100) |
| α-synuclein | Y125 | ND | (101) |
| c-Cbl | ND | ND | (102) |
| N-WASP | Y253 | Arp2/3 complex mediated actin polymerization Neurite extension |
(103) |
| Dab1 | Y185,Y198 | Permits phosphorylation of other Y sites of Dab1 Increases interaction with Fyn Akt activation Degradation of Dab1 |
(32) (31) (104) |