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. Author manuscript; available in PMC: 2016 Apr 28.
Published in final edited form as: J Am Coll Cardiol. 2015 Apr 28;65(16):1668–1682. doi: 10.1016/j.jacc.2015.03.043

Central Illustration. Methodological Recommendations to Enhance Clinical Trial Success Through Increased Event Rates.

Central Illustration

Previous and ongoing clinical trial inclusion criteria and methodological considerations are presented with recommendations to highlight the complexity of clinical trial design with associated recommendations to enhance event rates and future clinical trial success. CPET = cardiopulmonary exercise testing; EF = ejection fraction; HF = heart failure; HFpEF = heart failure with preserved ejection fraction; NP= natriuretic peptide; NT-proBNP = N-terminal pro-B-type natriuretic peptide.

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