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. 2016 Jan;186(1):134–144. doi: 10.1016/j.ajpath.2015.09.013

Figure 2.

Figure 2

Targeted inhibition of CRHR2 signaling in the colonic mucosa after DSS colitis exacerbates histological damage scores. Colon length (A) and representative H&E-stained sections (B) on day 14 from DSS-treated mice that received Ast2B or vehicle via daily i.c. injections after DSS colitis. Quantification of total histological damage score (C), crypt damage score (D), PMN infiltrate (E), and epithelial regeneration (F) at day 14. Data are expressed as means ± SEM. n = 8 mice per group. ∗P < 0.05 versus vehicle-treated controls. Scale bar = 100 μm. Ast2B, astressin 2B; CRHR2, corticotropin-releasing hormone receptor 2; DSS, dextran sodium sulfate; H&E, hematoxylin and eosin; i.c., intracolonic; PMN, polymorphonuclear.