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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Thorac Oncol. 2016 Jan;11(1):52–61. doi: 10.1016/j.jtho.2015.09.015

Figure 2. Chromosomal Position, Gene Structure, Protein Domain(s), and Sequence of the Candidate Mutations of CCDC147 and DBH Genes.

Figure 2

The mutations were confirmed with Sanger sequencing and indicated with red arrows. CCDC147 includes two coiled coil regions: 106–595 AA, and 642–839 AA. DBH consist of five domains: TM (transmembrane; 20–37 AA), DOMON (dopamine beta-monooxygenase N-terminal; 56–172 AA), Cu2_N (Copper type II, N-terminal; 213–341 AA), Cu2_C (Copper type II, C-terminal; 360–524 AA), and DBM (DB-monooxygenase motif IX; 552–572 AA).