Table 2.
Baseline characteristics of type 2 diabetic patients who underwent renal biopsy
| Parameter | Group I (n=10) | Group II (n=11) | Group III (n=54) | P |
|---|---|---|---|---|
| Age (y) | 65.0±13.1⁎ | 53.2±14.9 | 54.6±14.1⁎ | NS |
| M:F ratio | 9:1 | 10:1⁎ | 1.35:1⁎ | 0.024 |
| DM duration (y) | 8.3±7.5 | 9.6±7.9 | 4.2±4.8 | 0.008 |
| Presence of DR | 5/9 (55.6) | 7/10 (70.0)⁎ | 11/46 (23.9)⁎ | 0.008 |
| Laboratory data HbA1c (%) | 7.11±1.60 | 7.17±1.30 | 6.87±1.28 | NS |
| 24 h UP (mg/d) | 5274.2±5749.5 | 4564.5±2354.6 | 4077.3±5372.6 | NS |
| eGFR (mL/min/1.73m2) | 51.0±31.0 | 33.4±21.1⁎ | 61.5±31.9⁎ | 0.022 |
| BUN (mg/dL) | 26.3±15.1⁎ | 42.4±16.0⁎ | 26.8±19.2⁎ | 0.037 |
| Cr (mg/dL) | 2.1±1.4 | 3.2±2.4 | 2.0±2.0 | NS |
| Albumin (g/L) | 3.2±1.1 | 2.9±0.7 | 3.2±1.0 | NS |
| TG (mg/dL) | 256.9±126.7⁎ | 145.7±55.9⁎ | 252.6±237.9 | NS |
| Total cholesterol (mg/dL) | 224.7±95.0 | 197.2±49.5 | 234.3±137.9 | NS |
| CRP (mg/dL) | 0.2±0.1 | 1.4±3.1 | 1.4±3.3 | NS |
| C3 (mg/dL) | 87.0±19.4 | 103.4±22.6 | 101.5±30.6 | NS |
| C4 (mg/dL) | 36.6±9.0 | 36.9±9.4 | 30.7±17.2 | NS |
| IgG (mg/dL) | 967.7±375.9 | 1179.0±535.4 | 1072.4±537.8 | NS |
| IgA (mg/dL) | 273.7±120.5 | 347.8±194.6 | 304.5±145.3 | NS |
| IgM (mg/dL) | 92.0±65.0 | 126.6±98.0 | 139.4±77.4 | NS |
Data are presented as mean±SD or positive count/total count (%).
BUN, blood urea nitrogen; Cr, creatinine; CRP, C-reactive protein; DM, diabetes mellitus; DR, diabetic retinopathy; Ig, immunoglobulin; NS, nonsignificant value; UP, urine total protein.
⁎
Statistically significant findings in analysis between two groups: between Groups I and II – serum BUN (P=0.029), triglyceride (P=0.025); between Groups I and III – age at biopsy (P=0.039); and between Groups II and III – sex (P=0.036), presence of diabetic retinopathy (P=0.016), baseline eGFR (P=0.002), serum BUN (P=0.012).