FIGURE 4.

Comparison of direct cross-species prion transmission in the S. cerevisiae and S. paradoxus cell environments. A, frequency of [PSI⁺] transmission from S. cerevisiae Sup35 proteins to proteins with divergent or chimeric prion domains (as indicated). The data obtained from the S. cerevisiae cell environment (blue) have been published previously by Chen et al. (20) I, II, and III refer to the exchangeable modules of the PrD. B, phenotypes of [PSI⁺] produced from direct transmission in S. paradoxus. -Ade and YPD plates were photographed after 8 days.