Models for aging-associated changes in energy metabolism and aging.
A and B, models for the role of reciprocal changes in PEPCK-C and PK in aging. C, a model for the metabolic function of PEPCK-C. Red, pathways of the removal and replenishment of citric acid cycle intermediates by PEPCK-C; yellow, conversion of pyruvate to lactate; green, carbon dioxide generated from the oxidation of C5 of glutamate; αKG, α-ketoglutarate.