Table 1.
Demographics, laboratory data, and morphologic findings in patients with warfarin-related nephropathy (WRN)⁎
| Patient | Age | Gender | Race | Maximal INR (IU) | SCr change from BL (mg/dL) | Urinalysis | ATN | RBC casts (%) | Immunofluorescence | GBM thickness (nm)† | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 27 | F | AA | 8.0 | 2.5 | 3+ hematuria, 1+ proteinuria | 1+ | 2.8 | 1+ mesangial IgG, IgM, C1q, C3 | 560±120 | Renal function recovery |
| 2 | 76 | F | W | 7.0 | 2.5 | 2+ hematuria | 3+ | 20.9 | Nonspecific | 350±63 | Dialysis |
| 3 | 61 | M | W | 2.0 | 1.8 | 2+ hematuria, 3+ proteinuria | 2+ | 4.4 | Nonspecific | 357±101 | Dialysis, expired |
| 4 | 80 | M | W | 5.2 | 2.6 | 2+ hematuria, 2+ proteinuria | 3+ | 16.8 | 1+ mesangial IgA | 429±85 | Dialysis |
| 5 | 38 | F | W | 3.9 | 1.3 | 1+ hematuria, 1+ proteinuria | 1+ | 2.3 | 1+ mesangial IgA | 277±73 | Renal function recovery |
| 6 | 63 | M | W | 3.7 | 1.5 | 2+ hematuria, RBC casts | 1+ | 16.3 | Nonspecific | 430±99 | Partial renal function recovery |
| 7 | 82 | F | W | 2.8 | 3.4 | 1+ hematuria | 2+ to 3+ | 17.8 | 1+ mesangial IgA | 289±76 | Renal function recovery |
| 8 | 73 | M | W | 3.0 | 3.9 | 2+ hematuria, 3+ proteinuria | 3+ | 10.9 | Nonspecific | 310±89 | Dialysis |
| 9 | 55 | M | W | 3.8 | 8.3 | 1+ hematuria, 1+ proteinuria | 3+ | 11.4 | 1+ mesangial IgG, C1q, C3 | 343±148 | Renal function recovery |
†The mean GBM thickness established in our laboratory for males was 373±56 nm and for females was 351±40 nm.
AA, African American; ATN, acute tubular necrosis; BL, baseline; C, complement; GBM, glomerular basement membrane; Ig, immunoglobulin; INR, international normalized ratio; IU, international units; RBC, red blood cell; SCr, serum creatinine; W, white.
⁎
Morphological findings were scored semiquantitatively using the following criteria: 0, absent; 1+, mild; 2+, moderate; 3+, prominent. If changes were minimal but not absent, the score of +/− was applied.