Skip to main content
. 2015 Dec 7;9:112–122. doi: 10.2174/1874613601509010112

Fig. (3).

Fig. (3)

Increased proviral copies of HERV-K102 pol may be associated with resistance to HIV-1 acquisition. DNA was extracted from plasma and the HERV-K102 pol ddCt ratio was performed with respect to 18S RNA as previously described [3] on UNG treated templates to ensure genomic DNA and not particle associated cDNA was assessed. Individual ddCt ratios were plotted: Light blue = 16 Canadian HIV-1 patients on antiretroviral therapy (HIV-1 T) with a mean genomic copy ratio of 1.07 +/- 0.14. Dark blue = 10 Canadian HIV-1 patients not on antiretroviral therapy (HIV-1 NT) with a mean of 1.16 +/- 0.21. Note there was no statistical difference in the genomic copy ratios of HERV-K102 pol between the Canadian HIV-1 infected patients whether or not they were on therapy and neither group alone or together was statistically different from normal. Pink = Commercial Sex Workers (CSW) who had shown at least 3 years of HIV-1 resistance to transmission despite daily exposures to HIV-1 [15,16] with a mean genomic copy ratio of 4.21 +/-0.73. This was significantly elevated above normal (0.88 +/-0.37; p<0.0005) and above the 2 standard error cutoff of 1.62 (N=30, data not shown).