Table 7.
12-month Pre-index demographic and clinical characteristics for hyperlipidemic patients with and without new CV events before matching
| History of CV event cohort | Modified CHD RE cohort | Moderate risk cohort | Low risk cohort | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Without CV events | With CV events | Without CV events | With CV events | Without CV events | With CV events | Without CV events | With CV events | |||||||||
| (N = 10744) | (N = 77163) | (N = 145642) | (N = 156793) | (N = 11816 | (N = 14544) | (N = 16083) | (N = 18665) | |||||||||
| Mean [%]/(SD) | Mean [%]/(SD) | P-valuea | STD | Mean [%]/(SD) | Mean [%]/(SD) | P-valuea | STD | Mean [%]/(SD) | Mean [%]/(SD) | P-valuea | STD | Mean [%]/(SD) | Mean [%]/(SD) | P-valuea | STD | |
| Age | 73.66 (13.15) | 66.41 (13.65) | <0.0001 | 65.28 (13.16) | 65.17 (13.17) | 0.0189 | 67.83 (12.63) | 65.83 (12.83) | <0.0001 | 57.73 (12.45) | 54.56 (11.01) | <0.0001 | ||||
| 18-24 | [0.0 %] | [0.0 %] | 0.04 | 2.8 | [0.03 %] | [0.05 %] | 0.0018 | 1.1 | [0.00 %] | [0.00 %] | N/A | 0.0 | [0.2 %] | [0.2 %] | 0.3062 | 1.1 |
| 25-34 | [0.1 %] | [0.4 %] | <0.0001 | 6.6 | [0.3 %] | [0.4 %] | 0.0002 | 1.4 | [0.00 %] | [0.00 %] | N/A | 0.0 | [1.3 %] | [1.8 %] | 0.0016 | 3.4 |
| 35-54 | [6.9 %] | [18.4 %] | <0.0001 | 34.8 | [19.6 %] | [19.6 %] | 0.6784 | 0.2 | [11.7 %] | [16.7 %] | <0.0001 | 14.3 | [41.3 %] | [51.1 %] | <0.0001 | 19.8 |
| 55-64 | [22.1 %] | [32.1 %] | <0.0001 | 22.7 | [35.7 %] | [35.3 %] | 0.0122 | 0.9 | [38.0 %] | [41.2 %] | <0.0001 | 6.6 | [34.7 %] | [33.6 %] | 0.0327 | 2.3 |
| ≥65 | [70.9 %] | [49.2 %] | <0.0001 | 45.6 | [44.4 %] | [44.7 %] | 0.1341 | 0.5 | [50.3 %] | [42.1 %] | <0.0001 | 16.5 | [22.5 %] | [13.3 %] | <0.0001 | 24.1 |
| Male | [66.6 %] | [63.0 %] | <00001 | 7.7 | [62.2 %] | [61.1 %] | <0.0001 | 2.4 | [62.4 %] | [65.2 %] | <0.0001 | 5.9 | [60.2 %] | [66.4 %] | <0.0001 | 0.1 |
| US geographic region | ||||||||||||||||
| Northeast | [39.3 %] | [36.0 %] | <0.0001 | 6.8 | [35.3 %] | [34.9 %] | 0.0398 | 0.7 | [33.1 %] | [31.0 %] | 0.0003 | 4.5 | [35.8 %] | [31.4 %] | <0.0001 | 9.4 |
| Midwest | [22.1 %] | [25.5 %] | <0.0001 | 8.0 | [26.2 %] | [26.2 %] | 0.2635 | 0.4 | [27.2 %] | [28.2 %] | 0.0671 | 2.3 | [25.0 %] | [28.4 %] | <0.0001 | 7.6 |
| South | [24.4 %] | [26.3 %] | <0.0001 | 4.4 | [26.8 %] | [27.3 %] | 0.0006 | 1.3 | [26.0 %] | [28.3 %] | <0.0001 | 5.2 | [27.8 %] | [30.4 %] | <0.0001 | 5.7 |
| West | [14.2 %] | [12.2 %] | <0.0001 | 5.9 | [11.5 %] | [11.5 %] | 0.864 | 0.1 | [13.7 %] | [12.5 %] | 0.004 | 3.6 | [11.3 %] | [9.8 %] | <0.0001 | 5.0 |
| Baseline comorbid condition | ||||||||||||||||
| Charlson comorbidity index (CCI) | 2.72(2.15) | 3.30(2.65) | <0.0001 | 24.3 | 0.99(1.49) | 2.10(2.27) | <0.0001 | 57.6 | 0.53 (1.23) | 0.92(1.69) | <0.0001 | 26.6 | 0.22(0.78) | 0.33 (1.05) | <0.0001 | 11.4 |
| Chronic disease score | 5.28(4.06) | 6.01(4.44) | <0.0001 | 17.0 | 3.91(3.48) | 5.70(4.24) | <0.0001 | 46.2 | 4.17 (3.04) | 4.70(3.40) | <0.0001 | 16.6 | 1.16(1.94) | 1.28 (2.22) | <0.0001 | 5.8 |
| Baseline number of inpatient visits PPPM | 0.19(0.49) | 0.39(0.84) | <0.0001 | 28.8 | 0.04(0.19) | 0.18(0.52) | <0.0001 | 36.1 | 0.03 (0.19) | 0.10(0.35) | <0.0001 | 24.3 | 0.01 (0.07) | 0.03 (0.20) | <0.0001 | 15.6 |
CHD RE coronary heart disease risk equivalent, SD standard deviation, STD standardized difference, CV cardiovascular, CVD cardiovascular disease, PPPM per patient per month
aChi-square tests were used to evaluate the statistical significance of differences in categorical variables; student t-tests were used for the continuous variables