Fig. 5.

Viral infection history does not explain the presence of ERV-specific T cell responses in r02120. a Twenty-four rhesus macaques were screened for previous viral infections by plasma serology. Plasma was tested for antibodies against Simian T Lymphotropic virus (STLV), Simian Retrovirus Groups 1 and 5 (SRV1 and SRV5), Measles virus, Herpes B virus, Herpes Simplex virus type 1 (HSV-1), Cytomegalovirus (CMV), Lymphocryptovirus (LCV), Rhesus rhadinovirus (RRV), and Simian Foamy Virus (SFV). Rhesus macaque r02120, the only macaque in this group with detectable SERV-K1 Env-specific T cell responses, is boxed in blue. Note previous infection history does not explain r02120’s ability to mount SERV-K1 Env-specific immune responses (for example, r02120 and r07046 have identical plasma serology against these tested viruses). b Longitudinal ELISPOT values for IFN-γ spot forming cells (SFCs) measured in r02120 PBMC against either SERV-K1 Env LL15, SERV-K1 Env PA8, or SIV Vif WY8 are shown as mean ± SD of triplicate wells performed at the indicated times. The grey box indicates pre-SIV infection