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. 2016 Jan 15;23:2. doi: 10.1186/s12929-016-0218-7

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© Tsui et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Treatment with YC-1 enhances ox-LDL-mediated foam cell formation. a YC-1 increased intracellular lipid droplets in ox-LDL-treated macrophages. RAW 264.7 macrophages were treated with 20 μM YC-1 with/without 50 μg/mL ox-LDL for 24 h. After fixation and staining with oil red O, the cells were observed by light microscopy. Scale bar = 30 μm. b Treatment with ox-LDL decreased the cell viability of macrophages. RAW 264.7 macrophages were treated with 20 μM YC-1 with/without 50 μg/mL ox-LDL for 24 h and the cell viability was measured by MTT assay (n = 6). c Quantification of total lipid content of macrophages (n = 6). * indicates P < 0.05 compared to the control group; # indicates P < 0.05 compared to the ox-LDL-treated group