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. 2015 Oct 19;30(2):635–652. doi: 10.1096/fj.15-275859

Figure 3.

Figure 3.

DMP-GHRKO mice had an impaired bone response to iPTH. Female mice were injected once daily with 80 μg/kg PTH from 4 to 8 wk of age. A) Serum FGF23 levels in female control and the DMP-GHRKO mice treated with iPTH or vehicle from 4 to 8 wk. B) Serum 1,25-vitamin D levels in female control and DMP-GHRKO mice treated with iPTH or vehicle from 4 to 8 wk. C) Femurs were dissected at 8 wk of age and analyzed with micro-CT (the detailed traits are shown in Table 5). Fold change in bone traits obtained by micro-CT (in response to iPTH). The traits obtained from mice treated with PBS were used as the baseline. D) Micro-CT images of control and DMP-GHRKO bones from mice treated with PBS or iPTH. E) Gene expression in cortical bones from control and DMP-GHRKO female mice treated with PBS or iPTH from 4 to 8 wk of age. NS, not significant. Data are presented as means ± sem. *P < 0.05.