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Islets isolated from transgenic thDISC1 mice have decreased levels of β-cell-specific transcription factors and secrete less insulin when stimulated with glucose. A) Quantitative RT-PCR for mRNA levels (relative to ActinB) of mouse insulin, Nkx6.1, Pdx1, and Neurogenin 3 in DOX-treated thDISC1 mice (red) as compared with control (blue). B) Islet perifusion at 10 wk, n = 3. Means ± sem. *P < 0.05, Student’s t test; **P < 0.01 vs. corresponding controls.
