Skip to main content
. 2015 Nov 6;30(2):983–993. doi: 10.1096/fj.15-279810

Figure 6.

Figure 6.

DISC1 is important for proliferation and survival of pancreatic β cells. A) Postnatal day 2 control and hDISC1 mice pancreas 17 h after BrdU injection stained with insulin (pink), glucagon (green), BrdU (red), and DAPI (blue). BrdU-positive insulin cells (arrows), exocrine pancreas BrdU-positive cells (arrowheads). Scale bar, 20 μm. B) Quantitation of BrdU-positive β cells (total β cells counted: n = 3700 controls and n = 8391 thDISC1) and α cells (total α cells counted: n = 1670 controls and n = 4092 thDISC1) from 4 control and 8 thDISC1 mice. C) TUNEL staining in thDISC1 mouse islets showing TUNEL-positive staining in β cell (arrow); enlargement on the bottom, and TUNEL-positive cell in the exocrine pancreas (arrowhead); Quantitation of percent TUNEL-positive β cells; β cells counted: n = 1130 for control (n = 4 mice) and n = 2487 for thDISC1 (n = 7 mice). Means ± sem. **P < 0.01 vs. corresponding controls.