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We compared Rho+ cells in 2 groups of C57black6 mice (normal and BCAO-induced ocular ischemia) using anti-Rho-SPION-Ran and MRI. MRI data showed significantly higher levels of Rho+ signal in normal retinas compared to retinas of BCAO mice (A). Ex vivo validation shows dark stain as EDNs in rods and cones of photoreceptor cells (B), with fewer EDNs in BCAO retina (C).
