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. Author manuscript; available in PMC: 2017 Jan 7.
Published in final edited form as: Mol Cell. 2015 Dec 24;61(1):39–53. doi: 10.1016/j.molcel.2015.11.004

Figure 6. KAP1 and the 7SK snRNP Co-occupy Most Promoter-Proximal Regions Containing Paused Pol II.

Figure 6

(A) Heatmap representation of factor distribution at all RefSeq genes relative to the TSS and GRO-seq in the HCT116 cell line. All heatmaps are clustered to Pol II.

(B) Metagene analysis showing the distribution of each marker relative to the TSS.

(C) The number of genes containing Hexim1, Larp7, and Cdk9 (7SK snRNP target genes) at promoter-proximal regions was calculated.

(D) The number of genes containing the 7SK snRNP, KAP1, and paused Pol II at promoter-proximal regions was calculated. Genes containing all three markers are referred to as KEC target genes.

(E) Genome browser view of ChIP-seq at the KEC target gene TNFAIP3 along with GRO-seq data showing transcripts from the Watson (blue) and Crick (red) DNA strands.

See also Figure S4.