. Author manuscript; available in PMC: 2016 Jan 15.

Published in final edited form as: Horm Metab Res. 2008 May;40(5):329–337. doi: 10.1055/s-2008-1073156

Table 1.

Sensitivity and specificity of measurements of plasma fractionated metanephrines for diagnosis of pheochromocytoma

Center	Method	Diagnosis		URL (pg/ml)		Diag Accuracy		Ref.
Center	Method	P-Yes	P-No	NMN	MN	Sens	Spec	Ref.
NIH	HPLC	214	644	112	61	99 %	89 %	[8]
Vienna	HPLC	17	14	121	61	100 %	100 %	[7]
Mayo Clinic	HPLC	56	445	165	99	96 %	85 %	[9]
University of Essen	RIA	24	126	126	37	96 %	79 %	[10]
Sternberk Hospital	HPLC	25	1 235	112	61	100 %	97 %	[11]
All Centers	–	336	2 464	–	–	98 %	92 %	–

Abbreviations: P-Yes: number of patients with pheochromocytoma; P-No: number of patients in whom pheochromocytoma was excluded; URL: upper reference limits of reference intervals; NMN: normetanephrine; MN: metanephrine; Diag Accuracy: Diagnostic accuracy; Sens: Diagnostic sensitivity; Spec: Diagnostic specificity