Table 3.
Mortality rates/1000 person years (number of deaths) and adjusted hazards ratios (95%CI) for total mortality in men without CHD, stroke or heart failure.
| Serum sodium (mEq/L) | |||||
|---|---|---|---|---|---|
| <136 (N = 207) | 136–138 (N = 698) | 139–143 (N = 2029) | 144 (N = 109) | ≥145 (N = 56) | |
| Total mortality (n = 873) | |||||
| Rate/1000 per-yrs (n) | 43.9 (83) | 34.8 (230) | 24.6 (508) | 30.7 (33) | 35.4 (14) |
| Age-adjusted | 1.47 (1.16,1.85) | 1.39 (1.19,1.62) | 1.00 | 1.19 (0.84,1.69) | 1.48 (0.94,2.34) |
| Model 1 | 1.30 (1.02,1.66) | 1.30 (1.11,1.53) | 1.00 | 1.25 (0.87,1.78) | 1.54 (0.97,2.44) |
| Model 2 | 1.27 (0.99,1.62) | 1.27 (1.08,1.49) | 1.00 | 1.27 (0.88,1.81) | 1.52 (0.96,2.41) |
| Model 3 | 1.24 (0.97,1.59) | 1.33 (1.13,1.56) | 1.00 | 1.20 (0.83,1.73) | 1.46 (0.92,2.32) |
| (With exclusiona) | 1.23 (0.94,1.63) | 1.22 (1.01,1.47) | 1.00 | 1.20 (0.83,1.73) | 1.53 (0.85,2.75) |
Model 1 = adjusted for age, cigarette smoking, alcohol intake, physical activity, social class, BMI, use of antihypertensive drugs, diabetes, lung function, systolic blood pressure and eGFR.
Model 2 = Model 1 + muscle mass.
Model 3 = Model 1 + muscle mass + CRP + alkaline phosphatase + NT-proBNP.
a
Exclude men with diuretic use, renal dysfunction (eGFR<60) and current smokers.