Skip to main content
. 2015 Nov 11;5(12):e00403. doi: 10.1002/brb3.403

Figure 6.

Figure 6

Altered expression of proinflammatory transcripts after FS and KA‐SE. (A, B) Levels of Tnf‐α and Il‐1b mRNA were significantly higher both immediately after 30 min exposure to hyperthermia (FS0) and 4 h after FS (FS4) than in controls. (C) Expression levels of Nos2 mRNA were markedly increased at FS0 but returned to baseline levels by FS4. (n = 3/group; one‐way ANOVAs for all genes: P < 0.0001; Tukey post hoc comparisons: **P < 0.01, ***P < 0.001). FS0 = immediately following 30 min of hyperthermia and 2.5 h after LPS injection. FS4 = 4 h after hyperthermia and 6.5 h after LPS injection. (D) Levels of Tnf‐α mRNA were significantly increased both 30 min (KA0) and 4 h (KA4) after the onset of KA‐induced convulsive seizures compared to controls. In contrast, Il‐1β (E) and Nos2 (F) did not increase significantly after KA seizures (n = 3/group; one‐way ANOVA: Tnf‐α and Nos2: P < 0.001, Il‐1β: P < 0.05; Tukey post hoc comparisons: **P < 0.01, ***P < 0.001). Each bar represents the mean ± SEM.