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. 2015 Oct 22;106(12):1750–1760. doi: 10.1111/cas.12825

Table 1.

Interrelationships between clinicopathological variables and tumor‐infiltrating cells

Variables CD3 CD4 CD8 FOXP3 FOXP3/CD4 BTLA BTLA/CD8 BTLA/CD4 Cbl‐b Cbl‐b/CD8 Cbl‐b/CD4
Low High P‐value Low High P‐value Low High P‐value Low High P‐value Low High P‐value Low High P‐value Low High P‐value Low High P‐value Low High P‐value Low High P‐value Low High P‐value
Age, years 0.302 0.033 0.063 0.016 0.837 0.046 0.242 0.046 0.630 0.302 0.535
<68 (n = 105) 56 49 60 45 59 46 61 44 53 52 45 60 48 57 45 60 54 51 49 56 50 55
≥68 (n = 106) 49 57 45 61 46 60 44 62 52 54 60 46 57 49 60 46 51 55 57 49 55 51
Gender 0.046 0.948 0.833 0.002 0.537 0.948 0.627 0.733 0.046 0.627 0.085
Female (n = 100) 57 43 50 50 49 51 61 39 52 48 50 50 48 52 51 49 57 43 52 48 56 44
Male (n = 111) 48 63 55 56 56 55 44 67 53 58 55 56 57 54 54 57 48 63 54 57 49 62
Tumor main location 0.308 0.009 0.422 0.681 0.025 0.158 0.617 0.845 0.422 0.158 0.025
Gf, Gb (n = 104, 46) 78 72 66 84 72 78 76 74 82 68 70 80 73 77 74 76 72 78 80 70 82 68
Gn, C (n = 40, 21) 27 34 39 22 33 28 29 32 23 38 35 26 32 29 31 30 33 28 26 35 23 38
T 0.538 0.295 0.060 0.951 0.023 0.023 <0.001 0.005 0.372 0.003 0.011
1, 2 (n = 28, 66) 49 45 43 51 40 54 47 47 55 39 55 39 62 32 57 37 50 44 58 36 56 38
3, 4 (n = 74, 43) 56 61 62 55 65 52 58 59 50 67 50 67 43 74 48 69 55 62 48 69 49 68
N 0.836 0.448 0.448 0.063 0.033 0.007 0.113 0.301 0.113 0.946 0.190
0 (n = 107) 54 53 56 51 56 51 60 47 61 46 63 44 59 48 57 50 59 48 54 53 58 49
1 (n = 104) 51 53 49 55 49 55 45 59 44 60 42 62 46 58 48 56 46 58 52 52 47 57
M 0.963 0.522 0.126 0.398 0.009 0.083 0.003 0.020 0.802 0.034 0.009
0 (n = 145) 72 73 70 75 67 78 75 70 81 64 78 67 82 63 80 65 73 72 80 65 81 64
1 (n = 66) 33 33 35 31 38 28 30 36 24 42 27 39 23 43 25 41 32 34 26 40 24 42
Histopathological grading 0.303 0.239 0.727 0.063 0.003 0.063 0.033 0.033 0.632 0.146 0.191
1 (n = 99) 53 46 45 54 48 51 56 43 60 39 56 43 57 42 57 42 51 48 55 44 54 45
2, 3, 4 (n = 62, 45, 5) 52 60 60 52 57 55 49 63 45 67 49 63 48 64 48 64 54 58 51 61 51 61
Lymphatic invasion 0.016 0.352 0.962 0.069 0.128 0.035 0.069 0.128 0.128 0.403 0.128
0 (n = 68) 42 26 37 31 34 34 40 28 39 29 41 27 40 28 39 29 39 29 37 31 39 29
1 (n = 143) 63 80 68 75 71 72 65 78 66 77 64 79 65 78 66 77 66 77 69 74 66 77
Venous invasion 0.010 0.537 0.436 0.083 0.022 0.083 0.022 0.146 0.146 0.058 0.022
0 (n = 88) 53 35 46 42 41 47 50 38 52 36 50 38 52 36 49 39 49 39 51 37 52 36
1 (n = 123) 52 71 59 64 64 59 55 68 53 70 55 68 53 70 56 67 56 67 55 68 53 70
Perineural invasion 0.148 0.442 0.295 0.372 0.002 0.735 0.045 0.372 0.951 0.110 0.023
0 (n = 94) 52 42 44 50 43 51 50 44 58 36 48 46 54 40 50 44 47 47 53 41 55 39
1 (n = 117 53 64 61 56 62 55 55 62 47 70 57 60 51 66 55 62 58 59 53 64 50 67
CD3 <0.001 <0.001 <0.001 0.005 0.063 0.046 0.002 0.063 0.302 0.046
Low (n = 105) 77 28 74 31 71 34 42 63 59 46 45 60 41 64 59 46 49 56 45 60
High (n = 106) 28 78 31 75 34 72 63 43 46 60 60 45 64 42 46 60 57 49 60 46
CD4 <0.001 <0.001 <0.001 0.007 0.011 <0.001 <0.001 0.003 <0.001
Low (n = 105) 81 24 70 35 29 76 62 43 43 62 35 70 67 38 42 63 37 68
High (n = 106) 24 82 35 71 76 30 43 63 62 44 70 36 38 68 64 42 68 38
CD8 <0.001 <0.001 0.630 <0.001 <0.001 0.016 <0.001 0.001
Low (n = 105) 71 34 37 68 54 51 29 76 37 68 61 44 32 73 40 65
High (n = 106) 34 72 68 38 51 55 76 30 68 38 44 62 74 32 65 41
FOXP3 0.001 <0.001 0.945 0.837 0.001 0.449 0.837
Low (n = 105) 64 41 68 37 52 53 53 52 64 41 50 55 53 52
High (n = 106) 41 65 37 69 53 53 52 54 41 65 56 50 52 54
FOXP3/CD4 0.063 <0.001 <0.001 0.837 <0.001 <0.001
Low (n = 105) 59 46 69 36 75 30 53 52 68 37 74 31
High (n = 106) 46 60 36 70 30 76 52 54 39 67 31 75
BTLA <0.001 <0.001 <0.001 <0.001 0.016
Low (n = 105) 80 25 78 27 69 36 67 38 61 44
High (n = 106) 25 81 27 79 36 70 39 67 44 62
BTLA/CD8 <0.001 0.007 <0.001 <0.001
Low (n = 105) 88 17 62 43 80 25 70 35
High (n = 106) 17 89 43 63 26 80 35 71
BTLA/CD4 0.033 <0.001 <0.001
Low (n = 105) 60 45 73 32 73 32
High (n = 106) 45 61 33 73 32 74
Cbl‐b <0.001 <0.001
Low (n = 105) 76 29 75 30
High (n = 106) 30 76 30 76
Cbl‐b/CD8 <0.001
Low (n = 105) 90 16
High (n = 106) 15 90

Density ratios are shown of FOXP3 to CD4 (FOXP3/CD4), B and T lymphocyte attenuator (BTLA) to CD8 (BTLA/CD8), BTLA to CD4 (BTLA/CD4), Casitas–B‐lineage lymphoma protein‐b (Cbl‐b) to CD8 (Cbl‐b/CD8), and Cbl‐b to CD4 (Cbl‐b/CD4). Bold values, P < 0.05; underlined values, positively correlated. C, cystic duct; Gb, gallbladder body; Gf, gallbladder fundus; Gn, gallbladder neck.