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. 2015 Oct 16;106(11):1544–1553. doi: 10.1111/cas.12810

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Involvement of NEU3 in epidermal growth factor (EGF)‐induced elevation of MMP9 expression in head and neck squamous cell carcinoma cells. (a) Attenuation of EGF‐induced MMP9 elevation in NEU3‐silenced HSC‐2 and SAS cells in terms of mRNA levels. (b) Attenuation of EGF‐induced MMP2 and MMP9 secretion and activity by NEU3 silencing in HSC‐2 cells, as assessed by gelatin zymography. (c) Enhanced phosphorylation of EGF receptor (EGFR), ERK, and Akt by NEU3 overexpression and its reduction by NEU3 silencing, as assessed by Western blotting. Each value shown under the blot represents a value relative to that in the vector control (Vec) without EGF. (d) Abrogation of NEU3‐mediated as well as EGF‐induced augmentation of MMP9 expression by EGFR inhibitor AG1478.