Table 1.
Identification of host factors involved in the early stages of hepatitis B virus (HBV) replication in Huh7/NTCP cells
| Gene symbol | HBV/NL infection, %† | Cell viability, %‡ | Gene symbol | HBV/NL infection, %† | Cell viability, %‡ |
|---|---|---|---|---|---|
| CD2BP2 | 62 | 92 | PON2 | 57 | 85 |
| FBP1 | 62 | 92 | TRAF2 | 64 | 95 |
| GORASP2 | 44 | 86 | MCL1 | 56 | 104 |
| DUSP8 | 56 | 82 | DUSP5 | 49 | 97 |
| IL1RAP | 54 | 98 | PIK3R1 | 60 | 95 |
| RASA4 | 60 | 102 | IQCB1 | 57 | 91 |
| MTA2 | 51 | 106 | SART3 | 59 | 97 |
| GNAO1 | 51 | 94 | RLBP1L2 | 45 | 88 |
| RARA | 53 | 83 | IGFBPL1 | 53 | 96 |
| SNX9 | 36 | 94 | SAFB | 41 | 93 |
| CC2D2A | 56 | 95 | LOC146909 | 55 | 93 |
| NUP155 | 55 | 90 | KRTAP2‐4 | 51 | 93 |
| MFSD3 | 55 | 96 | CASP4 | 53 | 110 |
| TRIM68 | 54 | 85 | EPB41L3 | 58 | 86 |
| SH3YL1 | 57 | 96 | SEL1L | 46 | 90 |
| LY6E | 47 | 82 | NEU2 | 40 | 92 |
| OBSCN | 57 | 100 | STRN | 59 | 110 |
| WDR26 | 49 | 95 | UNC93B1 | 52 | 85 |
| ZMAT3 | 59 | 102 | C12orf54 | 57 | 99 |
| SPCS1 | 54 | 97 | TRIM26 | 58 | 109 |
| TGFBR2 | 58 | 92 | NUDT15 | 57 | 93 |
| KAT5 | 212 | 88 | NPM3 | 202 | 98 |
| HNF4A § (ref. 3) | 56 | 95 | BclxL § (ref. 20) | 54 | 96 |
| NTCP1 § (ref. 18) | 55 | 102 | KPNB1 § (ref. 21) | 52 | 96 |
| CEBPA §(ref. 19) | 37 | 100 | CHORDC1 § (ref. 22) | 57 | 99 |
†NanoLuc (NL) activity level (%) in siRNA‐treated cells compared to control cells (transfected with non‐targeting siRNA). ‡Cell viability level in siRNA‐treated cells compared to control cells (transfected with non‐targeting siRNA). §Host factors previously implicated in HBV replication. Ref., reference.