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Kaplan–Meier plots of the association of the presence of total PIK3CA mutations of cfDNA with RFS: (a) BCSS and (b) the entire cohort. When the presence of total PIK3CA mutations of cfDNA was defined as either positive or negative, positive cases seemed to have a longer survival than negative ones in log‐lank test: (a) RFS, P = 0.0072; (b) BCSS, P = 0.016. BCSS, breast cancer‐specific survival; cfDNA, cell‐free DNA; RFS, relapse‐free survival.
