Fig. 2.

Model of reovirus attachment to JAM-A on the cell surface. A ribbon-trace model of full-length T3D σ1, extending from a schematic virion, with the known structure of the C-terminus (Chappell et al. 2002) in tricolor and the prediction for the N-terminus in gray. The predicted SA-binding site (Chappell et al. 2000; Dermody et al. 1990) is marked with a hexagon. The extracellular domains D1 and D2 of JAM-A (Prota et al. 2003) and schematic representations of the transmembrane (TM) and intracellular domains are shown in green. Asterisks indicate regions of flexibility. For clarity, only two JAM-A monomers are shown bound to σ1. Figure and legend modified from Kirchner et al. (2008)