TABLE 4.

Summary Table Delineating Helpful Markers in Differential Diagnosis of Renal Tumors

	Positive Markers	Negative Markers
Clear cell RCC	vim, keratin, EMA, CD10, RCCm Pax 2/8, CAIX	CK7, Ksp-cadherin, parvalbumin
Papillary RCC	Keratin, CK7, AMACR, RCCm	CD117, Ksp-cadherin, parvalbumin, WT1
Chromophobe RCC	E-cadherin, Ksp-cadherin, CD117, EMA, CK, CK7	vim, CAIX, and AMACR
Collecting duct	EMA, p63, CK7, HMWCK, Pax 2, Pax 8	CD10, RCCm, and CK20
Clear cell papillary RCC	CK7, Pax 2, Pax 8	AMACR, RCCm
Translocation RCC	TFE3, TFEB, CD10, RCCm	CK (or weak)
Oncocytoma	Ksp-cadherin, CD117, parvalbumin, S100A1	CK7, Moc31, EpCam, EABA, CD82
Metanephric adenoma	S100, WT1, CD57	AMACR, RCCm
RCC with sarcomatoid features	CK7, Pax 2/Pax 8, CD10, vim, and AMACR
Angiomyolipoma	HMB45, melan-A, and SMA	CK, CD10, RCCm, Pax 2, Pax 8
Urothelial carcinoma	CK, CK7, CK20, p63, thrombomodulin, uroplakin III	RCCm, CD10, Pax 2, Pax 8

EABA indicates endogenous avidin-binding activity; vim, vimentin.