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. 2016 Jan 11;11:203–212. doi: 10.2147/IJN.S97207

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© 2016 Dai et al. This work is published and licensed by Dove Medical Press Limited

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Schematic of DIP-functionalized FRET near infrared (NIR) polymer nanoparticles.

Notes: MEH-PPV polymer initially absorbed excitation energy to produce visible emission, and then transferred visible emission’s energy to NIR775 dye to form NIR emission. They were coated by an amphiphilic polymer PS-PEG-COOH to produce fluorescence nanoparticles with water solubility and biocompatibility. Dipeptide Ser–Glu was conjugated to the nanoparticles’ surface for tumor targeting.

Abbreviations: MEH-PPV, poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]; NIR775, silicon 2, 3-naph-thalocyaninebis (trihexylsilyloxide); DIP, dipeptide; FRET, fluorescence resonance energy transfer; NPs-DIP, Ser–Glu-functionalized NPs.