Table 2.

Association of 6 IL-17A polymorphisms with AMD in NEI and AREDS cohorts

	MAF (%)		Uncorrected Model					Dominant Model
	Control	Case	P	OR	95% CI	HWE P	FDR	P/PA	ORA	95% CI
NEI
rs3748067	9.8	7.0	0.1587	0.70	(0.42–1.16)	0.6679	0.3471	0.5499	0.82	(0.43–1.57)
rs7747909	17.6	27.0	0.0022	1.73	(1.22–2.45)	0.8347	0.0126	0.0308	1.72	(1.05–2.83)
rs9395767	38.6	39.7	0.7613	1.05	(0.78–1.40)	0.2451	0.8595	0.7782	1.07	(0.66–1.75)
rs10484879	19.3	26.1	0.0257	1.48	(1.05–2.08)	0.9374	0.0817	0.0878	1.53	(0.94–2.51)
rs10484880	7.5	7.1	0.8044	0.93	(0.55–1.60)	0.9158	0.8798	0.4226	0.76	(0.39–1.49)
rs13205054	30.7	24.9	0.0704	0.75	(0.55–1.03)	0.8258	0.1760	0.3215	0.79	(0.49–1.27)
AREDS
rs7747909	25.4	25.4	0.9910	1.00	(0.75–1.34)	0.8800	0.9910	0.6960	0.93	(0.63–1.35)

rs7747909 and rs10484879 in IL-17A were found to be associated with AMD in the NEI cohort (p < 0.05). After logistic regression on the dominant model ({dd or Dd} vs. DD), correcting for age, smoking status, and gender, only rs7747909 in IL-17A had a p-value less than 0.05. rs7747909 did not replicate in the AREDS cohort.

Abbreviations: AREDS: Age-Related Eye Disease Study, CI: Confidence interval, FDR: False discovery rate, HWE: Hardy-Weinberg equilibrium, MAF: Minor allele frequency, NEI, National Eye Institute, OR: Odds ratio.