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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Neurochem Int. 2011 Oct 1;60(7):697–706. doi: 10.1016/j.neuint.2011.09.007

Figure 1.

Figure 1

Effect of cyclosporin A (CsA, 5 µM), an inhibitor of the mPT, on ammonia-induced release of lactate in cultured astrocytes. Following treatment of ammonia (5 mM NH4Cl, 24 h), culture medium was collected and lactate levels in the media were determined by an enzymatic assay employing lactate dehydrogenase that converts lactate to pyruvate (Kala and Hertz, 2005). Values are mean ± SEM of 10 individual plates in each experimental group obtained from two different seedings. * vs. control, p<0.01; ** vs. ammonia (NH4), p<0.01.