. Author manuscript; available in PMC: 2016 Nov 1.

Published in final edited form as: Ophthalmology. 2015 Sep 6;122(11):2286–2294. doi: 10.1016/j.ophtha.2015.07.029

Table 3b.

Joint Effects of AMD Genotype (based on CFH or ARMS2) and Healthy Lifestyle Score in Association with Odds for AMD among diet stable individuals

Genotype	No. with AMD/Total No. in Group	Most Healthy Lifestyles 4–6 (n=353)	3 (n=179)	Least Healthy Lifestyle 0–2 (n=196)	P-value^†	P-value for Multiplicative Interaction	Synergy Index (95% CI)
Genotype	No. with AMD/Total No. in Group	OR^* (95% CI)	OR^* (95% CI)	OR^* (95% CI)	P-value^†	P-value for Multiplicative Interaction	Synergy Index (95% CI)
CFH (rs1061170)
TT	34/276	1 [Reference]	0.96 (0.39, 2.39)	1.38 (0.58, 3.26)	0.51	0.31	1.34 (1.05, 1.70)
TC	58/339	1.69 (0.87, 3.28)	1.20 (0.52, 2.75)	1.70 (0.81, 3.55)	0.93
CC	28/114	1.56 (0.65, 3.71)	2.72 (0.97, 7.65)	4.63 (1.85, 11.60)	0.04

ARMS2 (rs10490924)
CC	70/457	1 [Reference]	0.67 (0.35, 1.32)	1.09 (0.59, 2.00)	0.94	0.16	1.65 (1.18, 2.30)
AC/AA	50/269	0.88 (0.48, 1.62)	1.40 (0.67, 2.94)	1.75 (0.92, 3.30)	0.07	0.16	1.65 (1.18, 2.30)

Adjusted for age (further adjustment for eye color and hormone therapy, or dietary LZ intake, did not alter ORs)

^†

P-values are for trend across lifestyle score group, within each genotype class.