Table 4a.
Joint Effects of AMD Genotype (based on CFH or ARMS2) and Dietary Lutein and Zeaxanthin (LZ) Intake in Association with Odds for AMD in overall sample
| Genotype | No. with AMD/Total No. in Group | High LZ Intake ≥2000 mcg/day (n=827) |
Low LZ Intake <2000 mcg/day (n=836) |
P-value for trend | P-value for Multiplicative Interaction | Synergy Index (95% CI) |
|---|---|---|---|---|---|---|
| OR* (95% CI) | OR* (95% CI) | |||||
| CFH (rs1061170) | ||||||
| TT | 92/606 | 1 [Reference] | 1.10 (0.70, 1.72) | 0.7 | 0.91 | 1.08 (0.55, 2.11) |
| TC | 163/791 | 1.46 (0.98, 2.19) | 1.42 (0.95, 2.13) | 0.83 | ||
| CC | 82/266 | 2.34 (1.41, 3.87) | 2.71 (1.66, 4.41) | 0.39 | ||
|
| ||||||
| ARMS2 (rs10490924) | ||||||
| CC | 179/1017 | 1 [Reference] | 0.96 (0.69, 1.33) | 0.81 | 0.47 | 1.44 (0.67, 3.12) |
| AC/AA | 158/643 | 1.44 (1.01, 2.04) | 1.65 (1.17, 2.32) | 0.49 | ||
|
| ||||||
| ARMS2 (rs10490924) | ||||||
| CC | 179/1017 | 1 [Reference] | 0.96 (0.69, 1.33) | 0.81 | 0.72 | 1.22 (0.53, 2.82) |
| AC | 136/575 | 1.32 (0.91, 1.91) | 1.63 (1.15, 2.32) | 0.29 | ||
| AA | 22/68 | 2.48 (1.18, 5.24) | 1.79 (0.79, 4.06) | 0.46 | ||
|
| ||||||
| CFB/C2 (rs641153) | ||||||
| AA/AG | 44/278 | 1 [Reference] | 0.69 (0.36, 1.35) | 0.24 | 0.18 | 1.85 (1.03, 3.33) |
| GG | 293/1385 | 1.21 (0.75, 1.95) | 1.37 (0.85, 2.20) | 0.35 | ||
|
| ||||||
| CFI (rs10033900) | ||||||
| GG | 92/430 | 1 [Reference] | 1.58 (0.97, 2.55) | 0.05 | 0.16 | 0.12 (2.7E-5, 535.7) |
| GA | 148/835 | 1.13 (0.72, 1.75) | 0.96 (0.61, 1.51) | 0.37 | ||
| AA | 97/397 | 1.55 (0.95, 2.55) | 1.56 (0.95, 2.56) | 0.95 | ||
|
| ||||||
| C3 (rs2230199) | ||||||
| CC | 17/69 | 1 [Reference] | 2.39 (0.72, 7.91) | 0.15 | 0.34 | 0.13 (1.9E-4, 89.0) |
| GC | 105/540 | 1.30 (0.47, 3.60) | 1.34 (0.48, 3.73) | 0.79 | ||
| GG | 214/1053 | 1.34 (0.49, 3.61) | 1.35 (0.50, 3.66) | 0.95 | ||
*
Adjusted for age (further adjustment for eye color, smoking, and hormone therapy did not alter ORs)