Table 5b.
Joint Effects of Complement Pathway Genotype (CFB/C2, CFI, and C3) and Healthy Lifestyle Score in Association with Odds for AMD among diet stable individuals
| Genotype | No. with AMD/Total No. in Group | Most Healthy Lifestyles 4–6 (n=353) |
3 (n=179)
|
Least Healthy Lifestyle 0–2 (n=196) |
P-value† | P-value for Multiplicative Interaction | Synergy Index (95% CI) |
|---|---|---|---|---|---|---|---|
| OR* (95% CI) | OR* (95% CI) | OR* (95% CI) | |||||
| CFB/C2 (rs641153) | |||||||
| AA/AG | 12/116 | 1 [Reference] | 1.08 (0.24, 4.94) | 1.38 (0.34, 5.63) | 0.76 | 0.99 | 1.16 (0.48, 2.81) |
| GG | 108/612 | 2.00 (0.75, 5.37) | 1.86 (0.66, 5.25) | 2.86 (1.04, 7.84) | 0.19 | ||
|
| |||||||
| CFI (rs10033900) | |||||||
| GG | 34/199 | 1 [Reference] | 1.03 (0.40, 2.61) | 1.13 (0.46, 2.77) | 0.78 | 0.18 | 1.43 (1.14, 1.80) |
| GA | 47/361 | 0.73 (0.37, 1.47) | 0.83 (0.37, 1.83) | 0.73 (0.33, 1.65) | 0.96 | ||
| AA | 39/168 | 1.22 (0.57, 2.63) | 0.71 (0.24, 2.10) | 2.90 (1.31, 6.41) | 0.05 | ||
|
| |||||||
| C3 (rs2230199) | |||||||
| CC | 29-Sep | 1 [Reference] | 0.86 (0.07, 11.11) | 4.72 (0.75, 29.65) | 0.10 | 0.95 | 1.08 (0.01, 169.2) |
| GC | 32/237 | 0.85 (0.22, 3.31) | 0.36 (0.08, 1.74) | 0.65 (0.14, 2.92) | 0.40 | ||
| GG | 79/462 | 0.69 (0.18, 2.59) | 0.90 (0.23, 3.54) | 1.07 (0.28, 4.09) | 0.13 | ||
*
Adjusted for age (further adjustment for eye color and hormone therapy, or dietary LZ intake, did not alter ORs)
†
P-values are for trend across lifestyle score group, within each genotype class.