Table 1.
Summary of Known Perinucleolar Region Regulators Protein or RNA
| Protein or RNA | Known Interphase Nuclear Localization |
Regulation Target (Species) |
|---|---|---|
| CTCF | Insulator Elements (Kim et al. 2007) | Insulators (H. sapiens)(Yusufzai et al. 2004) Clustered Centromeres (D. melanogaster) (Padeken et al. 2013) Xi (M. musculus) (Yang et al. 2015) |
| NLP (NCL) | Nucleolar Fibrillar Centers(Lischwe et al. 1981; Spector et al. 1984) Nucleolar Dense Fibrillar Component (Spector et al. 1984; Escande et al. 1985) Nucleolar Granular Component (Escande et al. 1985) |
Clustered Centromeres (D. melanogaster)(Padeken et al. 2013) |
| Modulo (NPM1) | Nucleolar Granular Component (Spector et al. 1984) | Clustered Centromeres (D. melanogaster) (Padeken et al. 2013) |
| CAF-1 p150 | DNA Damage Foci (Martini et al. 1998; Green and Almouzni 2003) Heterochromatin (Murzina et al. 1999) Perinucleolar Region (Smith et al. 2014) Replication Foci (Krude 1995) |
5S rDNA (H. sapiens) (Smith et al. 2014) Alpha Satellite DNA (H. sapiens) (Smith et al. 2014) D4Z4 (Chromosome 10q) (H. sapiens) (Smith et al. 2014) |
| Ki-67 | Satellite DNA (Bridger et al. 1998) Nucleolar Dense Fibrillar Component (Kill 1996) |
47S rDNA (H. sapiens) (Chromosome 13p) (Booth et al. 2014) |
| Kcnq1ot1 | Kcnq1 Locus (Pandey et al. 2008) | Kcnq1 locus (H. sapiens, M. musculus) (Pandey et al. 2008; Mohammad et al. 2008) |
| Firre | 6 gene-containing loci (Firre, Slc25a12, Ypel4, Eef1a1, Atf, Ppp1r10), and 34 non-gene loci (Hacisuleyman et al. 2014) | Xi (M. musculus) (Yang et al. 2015) |