Table 3.
Biodistribution of radioactivity after 8 days p.i. of 177Lu-complexes in Wistar rats
| Organ | [177Lu]citrate | [177Lu]BPAMD | [177Lu]BPAPD | [177Lu]BPPED | [177Lu]NO2APBP | [177Lu]DO2A(PBP)2 | [177Lu]DOTA(MBP)2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Blood | n.d. | n.d. | 0.001 | 0.000 | n.d. | n.d. | 0.001 | 0.001 | n.d. | n.d. | n.d. | n.d. | 0.003 | 0.001 |
| Brain | n.d. | n.d. | 0.004 | 0.001 | n.d. | n.d. | 0.014 | 0.021 | n.d. | n.d. | n.d. | n.d. | 0.018 | 0.007 |
| Pancreas | n.d. | n.d. | 0.006 | 0.001 | n.d. | n.d. | 0.005 | 0.003 | n.d. | n.d. | n.d. | n.d. | 0.067 | 0.019 |
| Spleen | n.d. | n.d. | 0.020 | 0.002 | n.d. | n.d. | 0.021 | 0.003 | n.d. | n.d. | n.d. | n.d. | 0.697 | 0.348 |
| Adrenal gland | n.d. | n.d. | 0.009 | 0.006 | n.d. | n.d. | 0.033 | 0.011 | n.d. | n.d. | n.d. | n.d. | 0.166 | 0.063 |
| Kidneys | n.d. | n.d. | 0.076 | 0.015 | n.d. | n.d. | 0.088 | 0.010 | n.d. | n.d. | n.d. | n.d. | 0.369 | 0.075 |
| Adipose tissue | n.d. | n.d. | 0.004 | 0.003 | n.d. | n.d. | 0.004 | 0.004 | n.d. | n.d. | n.d. | n.d. | 0.026 | 0.012 |
| Muscle | n.d. | n.d. | 0.136 | 0.107 | n.d. | n.d. | 0.027 | 0.056 | n.d. | n.d. | n.d. | n.d. | 0.024 | 0.003 |
| Heart | n.d. | n.d. | 0.006 | 0.001 | n.d. | n.d. | 0.008 | 0.001 | n.d. | n.d. | n.d. | n.d. | 0.099 | 0.024 |
| Lung | n.d. | n.d. | 0.008 | 0.001 | n.d. | n.d. | 0.008 | 0.002 | n.d. | n.d. | n.d. | n.d. | 0.117 | 0.045 |
| Thymus | n.d. | n.d. | 0.006 | 0.001 | n.d. | n.d. | 0.006 | 0.002 | n.d. | n.d. | n.d. | n.d. | 0.109 | 0.033 |
| Harderian gland | n.d. | n.d. | 0.105 | 0.127 | n.d. | n.d. | 0.113 | 0.132 | n.d. | n.d. | n.d. | n.d. | 0.331 | 0.131 |
| Liver | n.d. | n.d. | 0.025 | 0.002 | n.d. | n.d. | 0.027 | 0.003 | n.d. | n.d. | n.d. | n.d. | 0.470 | 0.078 |
| Testes | n.d. | n.d. | 0.004 | 0.000 | n.d. | n.d. | 0.004 | 0.001 | n.d. | n.d. | n.d. | n.d. | 0.050 | 0.005 |
| Femur | n.d. | n.d. | 5.039 | 0.453 | n.d. | n.d. | 5.197 | 0.435 | n.d. | n.d. | n.d. | n.d. | 7.340 | 1.009 |
Data are expressed in SUV. Each value represents the mean (S.D.) for five animals. As an exception are the data in three decimal places to show also the very low values
n.d. data not determined