Table 2.
Incidence of Intrahepatic Tumor and Extrahepatic Tumor in Direct Hepatic Implantation Model
| Rates for tumor incidence [n/N (%)] | Size of tumor in implantation site (mm), [means ± SD (range)] | Number of vascular invasion [means ± SD (range)] | Number of intrahepatic dissemination [means ± SD (range)] | |
|---|---|---|---|---|
| 4 Weeks (n = 2) | ||||
| Tumor formation | ||||
| Intrahepatic tumor | ||||
| Hepatic tumor in implantation site | 2/2 (100) | (2.0, 2.0) | (0, 1) | 0 |
| Satellite nodule | 1/2 (50) | |||
| Intrahepatic dissemination | 0/2 (0) | |||
| Extrahepatic tumor | ||||
| Peritoneum | 1/2 (50) | |||
| 8 Weeks (n = 6) | ||||
| Tumor formation | ||||
| Intrahepatic tumor | ||||
| Hepatic tumor in implantation site | 6/6 (100) | 7.8 ± 4.6 (3–15) | 1.8 ± 1.5 (0–3) | 7.7 ± 11.3 (0–30) |
| Satellite nodule | 6/6 (100) | |||
| Intrahepatic dissemination | 4/6 (66.7) | |||
| Extrahepatic tumor | ||||
| Peritoneum | 4/6 (66.7) | |||
| 12 Weeks (n = 6) | ||||
| Tumor formation | ||||
| Intrahepatic tumor | ||||
| Hepatic tumor in implantation site | 6/6 (100) | 8.5 ± 4.7 (2–15) | 3.7 ± 1.8 (1–5) | 7.0 ± 13.8 (0–35) |
| Satellite nodule | 6/6 (100) | |||
| Intrahepatic dissemination | 4/6 (66.7) | |||
| Extrahepatic tumor | ||||
| Peritoneum | 4/6 (66.7) | |||
| Regional lymph node of the stomach | 1/6 (16.7) | |||
Cell number to implant is 1.00 × 106 cells/20 μL.