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Circulating levels of BRAFV600E by pathologic diagnosis (benign, left; malignant, right) and tissue mutational status. Benign/BRAF− indicates a tumor that was read as either an adenoma or a benign hyperplastic lesion that is also negative for BRAFV600E by conventional tissue testing. Benign/BRAF+ indicates pathologically negative, tissue BRAFV600E+. Asterisk indicates patients with known distant metastatic disease.
