Table 3.

Sensitivity, Specificity, and Likelihood Ratio for Positive Tissue BRAF Test in Various Thresholds

BRAFV600E positivity threshold, pg	Sensitivity, %	Specificity, %	LR+
5	62.5	71.1	2.2
10	50.0	86.8	3.9
20	43.8	92.1	5.5

With the use of tissue results as the gold standard, proportion of true-positive (ie, sensitivity) and true-negative (ie, specificity) results of the blood test in predicting the tissue results were calculated at various positivity thresholds. Likelihood ratios (sensitivity/1 − specificity) were calculated, and a receiver-operating curve was produced.

LR⁺, likelihood ratio for positive tissue BRAF test.