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. 2014 Oct;184(10):2687–2698. doi: 10.1016/j.ajpath.2014.06.014

Figure 2.

Figure 2

Histopathology of fibrosis. A: Representative photomicrographs of MTS-stained kidney sections of wild-type control (32 weeks) and creatinine-matched Col4a3 KO and Col4a3;Tsp1 DKO mice. B: The degree of tubulointerstitial fibrosis (determined by relative interstitial volume) did not differ significantly between kidneys of Col4a3 KO and Col4a3;Tsp1 DKO mice. C: In MTS-stained kidney sections, the degree of collagen deposition (blue) was significantly higher in Col4a3 KO mice than in Col4a3;Tsp1 DKO mice. D: Fibrillar collagen content (determined as percent of total kidney protein) was higher in Col4a3 KO kidneys than in creatinine-matched Col4a3;Tsp1 DKO kidneys. Data are expressed as means ± SEM. *P < 0.05. Original magnification, ×20.