Table 1.
Effect of demographic and clinicopathologic characteristics of melanoma patients in the GEM study on disease-specific mortality
| Variable | N (%) | N events | HRa | 95% CIa | P valuea |
|---|---|---|---|---|---|
| Gender | |||||
| Male | 2004 (56.2) | 183 | 1 | <0.001 | |
| Female | 1562 (43.8) | 71 | 0.57 | 0.43–0.76 | |
| Age at diagnosis | |||||
| Continuous | — | 1.03 | 1.02–1.04 | <0.001 | |
| Site | |||||
| Head/neck | 575 (16.1) | 76 | 1 | <0.001 | |
| Trunk/pelvis | 1580 (44.3) | 107 | 0.55 | 0.41–0.75 | |
| Arms | 665 (18.7) | 34 | 0.47 | 0.31–0.70 | |
| Legs | 746 (20.9) | 37 | 0.51 | 0.34–0.78 | |
| Histology | |||||
| SSM | 2294 (64.3) | 105 | 1 | <0.001 | |
| NM | 332 (9.3) | 70 | 4.34 | 3.19–5.92 | |
| LM | 364 (10.2) | 18 | 0.84 | 0.51–1.40 | |
| NOS | 495 (13.9) | 40 | 1.83 | 1.26–2.67 | |
| Other | 81 (2.3) | 21 | 5.20 | 3.23–8.36 | |
| Breslow thickness | |||||
| 0.01–1.00 | 2223 (62.3) | 44 | 1 | <0.001 | |
| 1.01–2.00 | 723 (20.3) | 79 | 5.55 | 3.83–8.04 | |
| 2.01–4.00 | 359 (10.1) | 75 | 10.44 | 7.16–15.22 | |
| >4.00 | 175 (4.9) | 52 | 15.50 | 10.32–23.29 | |
| Missing | 86 (2.4) | 4 | |||
| Ulceration | |||||
| Absent | 2475 (69.4) | 140 | 1 | <0.001 | |
| Present | 262 (7.4) | 69 | 4.81 | 3.58–6.47 | |
| Missing | 829 (23.2) | 45 | |||
| Mitoses | |||||
| Absent | 1520 (42.6) | 41 | 1 | <0.001 | |
| Present | 1227 (34.4) | 169 | 5.05 | 3.59–7.11 | |
| Missing | 819 (23.0) | 44 | |||
Patients who entered the study with single primary melanoma and developed a subsequent melanoma were treated as time dependent. LM, lentigo maligna; NM, nodular melanoma; NOS, not otherwise specified; SSM, superficial spreading melanoma.
aAdjusted for study center, presence of multiple primary melanomas, time-dependent crossover status (patients who entered the study with single primary melanoma and developed a subsequent melanoma) and age at diagnosis of the first primary melanoma and sex.