Table 1.
Characteristics of colorectal cancer cases in study populations included in primary discovery analyses
| Health Professionals Follow-up Study | Nurses’ Health Study | Physicians’ Health Study | Prostate, Lung, Colon and Ovarian Cancer Screening Trial | VITamins and Lifestyle Study | Women’s Health Initiative | |||
|---|---|---|---|---|---|---|---|---|
| (Subset 1) | (Subset 2) | (Subset 1) | (Subset 2) | |||||
| Abbreviation | HPFS | NHS | PHS | PLCO1 | PLCO2 | VITAL | WHI1 | WHI2 |
| Genotyping platforma | 730K | 730K | 730K | 300/240S, 610K | 300K | 300K | 550K, 550Kduo, 610K | 300K |
| No. cases | 168 | 296 | 324 | 531 | 478 | 285 | 455 | 957 |
| No. deaths, total (% of cases) | 82 (49) | 118 (40) | 200 (62) | 180 (34) | 103 (22) | 117 (41) | 160 (35) | 263 (27) |
| No. deaths, CRC (% of deaths) | 47 (57) | 89 (75) | 131 (66) | 108 (60) | 77 (75) | 70 (60) | 115 (72) | 193 (73) |
| Median follow-up in years (SD) | 5.8 (3.7) | 6.7 (5.0) | 8.1 (7.2) | 6.6 (3.4) | 4.5 (3.6) | 4.9 (2.9) | 5.3 (3.5) | 4.2 (3.4) |
| % Female | 0 | 100 | 0 | 43 | 42 | 47 | 100 | 100 |
| Age at diagnosis, N (%) | ||||||||
| <65 years | 41 (24) | 101 (34) | 98 (30) | 125 (24) | 98 (21) | 61 (21) | 84 (18) | 160 (17) |
| 65–69 | 21 (13) | 66 (22) | 53 (16) | 145 (27) | 115 (24) | 57 (20) | 94 (21) | 205 (21) |
| 70–74 | 38 (23) | 63 (21) | 55 (17) | 161 (30) | 131 (27) | 96 (34) | 133 (29) | 242 (25) |
| 75–79 | 34 (20) | 46 (16) | 51 (16) | 88 (17) | 88 (18) | 58 (20) | 95 (21) | 196 (20) |
| ≥80 years | 34 (20) | 20 (7) | 67 (21) | 12 (2) | 46 (10) | 13 (5) | 49 (11) | 154 (16) |
| Stage at diagnosis, N (%) | ||||||||
| I/localized | 47 (36) | 61 (23) | 64 (28) | 193 (37) | 166 (35) | 135 (48) | 192 (43) | 427 (45) |
| II–III/regional | 61 (46) | 151 (58) | 121 (53) | 282 (54) | 246 (52) | 100 (36) | 197 (44) | 400 (42) |
| IV/distant | 24 (18) | 50 (19) | 44 (19) | 51 (10) | 65 (14) | 46 (16) | 61 (14) | 121 (13) |
| Unknown | 36 | 34 | 95 | 5 | 1 | 4 | 5 | 9 |
| Tumor site, N (%) | ||||||||
| Colon | 113 (75) | 228 (78) | 250 (78) | 514 (99) | 313 (66) | 215 (77) | 442 (98) | 701 (74) |
| Rectum | 38 (25) | 65 (22) | 70 (22) | 5 (1) | 160 (34) | 66 (23) | 10 (2) | 250 (26) |
| Unknown | 17 | 3 | 4 | 12 | 5 | 4 | 3 | 6 |
aAll platforms were Illumina assays.