Table 2.
Characteristics of colorectal cancer cases in study populations included in follow-up analyses
| MRC COIN and COIN B | Cancer Prevention Study II | Darmkrebs: Chancen der Verhütung durch Screening Study | Diet, Activity and Lifestyle Study | |||
|---|---|---|---|---|---|---|
| (Subset 1) | (Subset 2) | (Subset 1) | (Subset 2) | |||
| Abbreviation | COIN/COIN-B | CPS-II | DACHS1 | DACHS2 | DALS1 | DALS2 |
| Genotyping platforma | KASPar (targeted) | Custom Affymetrix Axiom array | 300K | 730K | 550K/610K | 300K |
| No. cases | 2234 | 523 | 1705 | 420 | 706 | 410 |
| No. deaths, total (% of cases) | 1612 (72) | 113 (22) | 573 (34) | 97 (23) | 241 (34) | 113 (28) |
| No. deaths, CRC (% of deaths) | Not available | 84 (74) | 414 (72) | 71 (73) | 133 (55) | 79 (70) |
| Median follow-up in years (SD) | 2.4 (2.2) | 2.8 (2.0) | 4.9 (1.7) | 2.9 (0.9) | 5.2 (2.5) | 4.6 (1.7) |
| % Female | 34 | 50 | 41 | 38 | 43 | 47 |
| Age at diagnosis, N (%) | ||||||
| <65 years | 1296 (58) | 12 (2) | 589 (34) | 149 (35) | 288 (41) | 161 (39) |
| 65–69 | 456 (20) | 79 (15) | 318 (19) | 66 (16) | 142 (20) | 85 (21) |
| 70–74 | 339 (15) | 138 (26) | 288 (17) | 78 (19) | 155 (22) | 96 (23) |
| 75–79 | 127 (6) | 172 (33) | 260 (15) | 61 (14) | 121 (17) | 68 (17) |
| ≥80 years | 14 (1) | 122 (23) | 250 (15) | 66 (16) | 0 (0) | 0 (0) |
| Stage at diagnosis, N (%) | ||||||
| I/localized | 0 (0) | 229 (46) | 412 (24) | 101 (24) | 260 (40) | 128 (35) |
| II–III/regional | 0 (0) | 223 (44) | 1051 (62) | 260 (63) | 331 (51) | 210 (58) |
| IV/distant | 2234 (100) | 51 (10) | 238 (14) | 55 (13) | 64 (10) | 27 (7) |
| Unknown | 0 | 20 | 4 | 4 | 51 | 45 |
| Tumor site, N (%) | ||||||
| Colon | 1017 (46) | 417 (81) | 1042 (61) | 234 (56) | 702 (100) | 410 (100) |
| Rectum | 1216 (54) | 101 (19) | 663 (39) | 186 (44) | 0 (0) | 0 (0) |
| Unknown | 1 | 5 | 0 | 0 | 4 | 0 |
aUnless otherwise stated, genotyping platforms were Illumina assays.