Table 1.

Circuits in Which a Challenge Dose of Nicotine Increased or Decreased the Strength of rsFC (p < .05)

Group	Increased rsFC	Decreased rsFC
3 hr	Nucleus accumbens–retrosplenial cortex	Caudoputamen–medial habenula
	Orbital frontal area–prelimbic area
6 hr	Anterior cingulate cortex–amygdala	Hippocampus–ventral tegmental area
	Amygdala–retrosplenial cortex	Ventral tegmental area–amygdala
	Insula–ventral tegmental area
	Insula–medial habenula
	Insula–orbital frontal area
	Orbital frontal area–substantia nigra
12 hr	Nucleus accumbens–retrosplenial cortex	Anterior cingulate cortex–interpeduncular nucleus
	Retrosplenial cortex–anterior cingulate cortex
24 hr	Nucleus accumbens–amygdala	Nucleus accumbens–infralimbic area
		Infralimbic area–caudoputamen
		Ventral tegmental area–interpeduncular nucleus
		Interpeduncular nucleus–retrosplenial cortex
		Orbital frontal area–medial habenula

Note. The groups indicate the number of hours expired between the administration of the nicotine challenge dose and the previous dose. rsFC = resting-state functional connectivity.